Genotypes Affecting the Pharmacokinetics of Anticancer Drugs

Genotypes Affecting the Pharmacokinetics of Anticancer Drugs

Cancer treatment is becoming more and more individually based as a result of the large inter-individual differences that exist in treatment outcome and toxicity when patients are treated using population-based drug doses. Polymorphisms in genes encoding drug-metabolizing enzymes and transporters can significantly influence uptake, metabolism, and elimination of anticancer drugs. As a result, th...

Chromatography of Anticancer Drugs

Chromatographic techniques have been developed and successfully applied for the analysis of a considerable of number of organic and inorganic compounds present at trace level in sometimes complicated accompanying matrices. The rapid development of new chromatographic instrumentation and separation strategies resulted in the increase of the number of chromatographic technologies with higher sepa...

Mechanisms of anticancer drugs

Introduction 34 Principles of chemotherapy 34 Principles of tumour biology 34 Classification of chemotherapeutic agents 37 Limitations of cytotoxic agents 40 Chemotherapy in head and neck cancer 40 Choice of chemotherapy in head and neck cancer 40 Chemotherapy strategies 40 Novel therapies for the future 41 Other novel treatments 44 Conclusion 44 Key points 45 Deficiencies in current knowledge ...

the role of nanocarrier on biofate of anticancer drugs

Pharmacokinetics of inhaled drugs.

1. A high therapeutic ratio for the inhaled route of administration is achieved by delivering doses which achieve a high local concentration in the lung and relatively low levels of systemic absorption. 2. Pharmacokinetic evaluation of drug absorption from the lungs provides an accurate and reproducible method for comparing different inhaler delivery systems, as well as for evaluating bioequiva...